Myo-inositol begins restoring ovulation within 3-5 weeks but achieves optimal pregnancy rates after 3-6 months of sustained treatment.

Myo-inositol demonstrates a hierarchical timeline of fertility effects, with the earliest measurable responses occurring within 1 week. Estradiol concentrations increased within the first week of treatment, representing the initial hormonal response. Functional ovulatory restoration occurred more gradually, with time to first ovulation at 24.5 days (95% CI: 18-31 days) compared to 40.5 days for placebo, and 88% of PCOS women experiencing their first spontaneous menstrual cycle after a mean of 34.6±5.5 days. Clinical pregnancies required sustained treatment, with large observational cohorts documenting 70% ovulation restoration and 15.1% pregnancy rates by 10.2 weeks, while extended 6-month protocols achieved 40% pregnancy rates. Significant hormonal changes, including testosterone reduction and progesterone elevation, were consistently documented after 12 weeks.

The optimal treatment duration depends on therapeutic context. For women seeking spontaneous conception, treatment should be sustained for 3-6 months to maximize pregnancy outcomes, while ovulatory effects become apparent within 4-5 weeks. For IVF protocols, 1-2 months of pre-treatment improved oocyte quality and fertilization rates. However, most studies were not designed with timing as a primary endpoint, and only one trial provided confidence intervals for time-to-event outcomes. The evidence suggests a dose-response relationship between treatment duration and pregnancy rates, though individual response varies based on baseline characteristics such as BMI

Full research report here: How long does it take for myo-inositol to work for fertility.

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