Fertility Inositol FAQs

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FAQs

Can inositol improve fertility?

Yes in some cases but not all. Fertility is a very complex matter and you need to consult a specialist health care professional.

How does inositol affect fertility?

Inositol may improve fertility by regulating insulin sensitivity, which can help to regulate menstrual cycles and improve egg quality in women with PCOS.

What dosage of inositol is best for fertility?

We recommend a dose of 4g per day taken as 2g in the morning with breakfast and 2g taken in the evening with dinner.

Can inositol be taken with other fertility supplements?

Inositol can generally be taken with other fertility supplements, but it is always best to speak with a healthcare provider before starting or stopping any new supplement regimen.

Is inositol safe to take during pregnancy?

Yes it is considered generally safe but it is always best to speak with your specialist healthcare provider before taking any supplement during pregnancy.

Can inositol help with male fertility?

Inositol has been studied for its potential to improve sperm quality and motility in men, but more research is needed to confirm these findings.

Can inositol be used as a natural alternative to fertility drugs?

Inositol may be used as a natural alternative to fertility drugs in some cases, but it is important to speak with a specialist healthcare provider before using any supplement to improve fertility.

Are there any side effects of inositol for fertility?

Inositol is generally well-tolerated, but some people may experience side effects such as nausea, headache, and dizziness. If you experience any adverse effects while taking inositol, stop taking the supplement and speak with a healthcare provider. For mild side effects we recommend the ramping protocol of 1g/day in week 1, 2g/day in week 2, 3g/day in week 3 and then the full 4g/day in week 4.

Why don't you sell a 40:1 D Chiro / Myo Inositol Blend.

The inositol problem in PCOS is that the body over converts Myo Inositol (MI) into D Chiro Inositol. (DCI) Adding more DCI isn’t the answer.

In PCOS patients with hyperinsulinemia, increased epimerase activity leads to excessive conversion of MI to DCI in the ovary, resulting in MI depletion and DCI overproduction (Nestler & Unfer, 2015; Unfer et al., 2014).

This imbalance may impair FSH signaling and oocyte quality (Nestler & Unfer, 2015). Studies have shown that the MI:DCI ratio in follicular fluid drops from 100:1 in healthy women to 0.2:1 in PCOS patients (Unfer et al., 2014).

The altered MI:DCI ratio may contribute to pathological steroidogenesis in PCOS, with DCI promoting androgen synthesis and reducing estradiol production (Unfer et al., 2020).

Restoring the appropriate MI:DCI ratio has shown efficacy in PCOS treatment, and MI supplementation may improve oocyte and sperm quality in assisted reproduction (Facchinetti et al., 2016).

In addition D-Chiro has negative long term effects.

Please read:

Nordio, M.; Bezerra Espinola, M.S.; Bilotta, G.; Capoccia, E.; Montanino Oliva, M. Long-Lasting Therapies with High Doses of D-chiro-inositol: The Downside. J.Clin. Med. 2023, 12, 390. https://doi.org/10.3390/jcm12010390

R. GAMBIOLI, G. FORTE, C. ARAGONA, A. BEVILACQUA, M. BIZZARRI, V. UNFER. The use of D-chiro-Inositol in clinical practice European Review for Medical and Pharmacological Sciences 2021; 25: 438-446

Still have questions? Check out our Inositol General FAQs and our PCOS Inositol FAQs