FAQs About Inositol

Research has not yet evaluated whether myo-inositol can balance hormones in healthy people without PCOS or fertility issues.

Myo-inositol—typically given at 2–4 g daily in combination with 200–400 μg folic acid—has been shown to improve ovarian parameters in women with polycystic ovary syndrome. In non‐PCOS women undergoing in vitro fertilization, one study reported that myo-inositol reduced gonadotropin requirements (2,084 ± 648 IU versus 2,479 ± 979 IU, p < 0.05) and modified luteinizing hormone levels (2.7 ± 1.1 vs. 1.6 ± 0.9, p < 0.01) while yielding fewer oocytes (5.9 ± 2.4 vs. 7.6 ± 3.8, p < 0.01) and producing no significant differences in pregnancy or implantation rates. No study has evaluated hormone balancing effects in healthy, non-infertile populations outside of the assisted reproduction setting. Mild gastrointestinal side effects have been noted at higher doses, although no substantial safety concerns were reported.

Myo-Inositol for Hormonal Balance – Report

References

Lisi, F., Carfagna, P., Oliva, M., Rago, R., Lisi, R., Poverini, R., Manna, C., Vaquero, E., Caserta, D., Raparelli, V., Marci, R., & Moscarini, M. (2012). Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study. Reproductive Biology and Endocrinology, 10(1), 52. https://doi.org/10.1186/1477-7827-10-52

Laganà, A. S., Vitagliano, A., Noventa, M., Ambrosini, G., & D’Anna, R. (2018). Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials. Archives of Gynecology and Obstetrics, 298(4), 675–684. https://doi.org/10.1007/s00404-018-4861-y

Sortino, M. A., Salomone, S., Carruba, M. O., & Drago, F. (2017). Polycystic Ovary Syndrome: Insights into the Therapeutic Approach with Inositols. Frontiers in Pharmacology, 8. https://doi.org/10.3389/fphar.2017.00341

Gerli, S., Papaleo, E., Ferrari, A., & Renzo, G. D. (2007). Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. European Review for Medical and Pharmacological Sciences.

F. R. C. “Computer S., Academy, I. S. M., V.I. Kulakov Research Center of Obstetrics, G. and P., & Academy, I. S. M. (2018). Myo-inositol: micronutrient for “fine tuning” of the female reproductive sphere. LLC Russian Medical Journal. https://doi.org/10.32364/2618-8430-2018-1-2-148-155

The inositol problem in PCOS is that the body over converts Myo Inositol (MI) into D Chiro Inositol. (DCI) Adding more DCI isn’t the answer.

In PCOS patients with hyperinsulinemia, increased epimerase activity leads to excessive conversion of MI to DCI in the ovary, resulting in MI depletion and DCI overproduction (Nestler & Unfer, 2015; Unfer et al., 2014). 

This imbalance may impair FSH signaling and oocyte quality (Nestler & Unfer, 2015). Studies have shown that the MI:DCI ratio in follicular fluid drops from 100:1 in healthy women to 0.2:1 in PCOS patients (Unfer et al., 2014). 

The altered MI:DCI ratio may contribute to pathological steroidogenesis in PCOS, with DCI promoting androgen synthesis and reducing estradiol production (Unfer et al., 2020). 

Restoring the appropriate MI:DCI ratio has shown efficacy in PCOS treatment, and MI supplementation may improve oocyte and sperm quality in assisted reproduction (Facchinetti et al., 2016).

In addition D-Chiro has negative long term effects.

Please read:

Nordio, M.; Bezerra Espinola, M.S.; Bilotta, G.; Capoccia, E.; Montanino Oliva, M. Long-Lasting Therapies with High Doses of D-chiro-inositol: The Downside. J.Clin. Med. 2023, 12, 390. https://doi.org/10.3390/jcm12010390

R. GAMBIOLI, G. FORTE, C. ARAGONA, A. BEVILACQUA, M. BIZZARRI, V. UNFER. The use of D-chiro-Inositol in clinical practice European Review for Medical and Pharmacological Sciences 2021; 25: 438-446

Inositol is a type of carbohydrate that is found in small amounts in various foods, including grains, fruits, and nuts. The product on this site is a dietary supplement made from corn.

In-os-it-ol

“How do you say inositol” Inositol Australia

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1. “How do you say inositol” — Inositol Australia

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If you have PCOS then give them a copy of the 2023 PCOS Evidence Based Guidelines here. Secondly ask them to look at the research papers linked here.  (two tabs in a spreadsheet.) Thirdly ask them to create an account with elicit.org and do some research themselves.

They are all the same ingredient – natural GMO free Myo Inositol. The dose differs between PCOS, Fertility, IR (4g /day) and Cognitive Health (15g/day). Also FAQs, Blog Posts and Reviews are divided by use category to make it easier to find relevant information. Post purchase support information is also divided by use.

It has been studied and the recommended approach is 2g in the morning and 2g in the evening to get a full 24 hour effect. 

Refer to

Finding the best therapeutic approach for PCOS: the importance of inositol(s)bioavailability.

• B. Orrù, R. Circo, G. Carlomagno
• Published 1 June 2017
• European review for medical and pharmacological sciences.

Our Myo Inositol does not contain ethyl alcohol and is Halal certified.