The inositol problem in PCOS is that the body over converts Myo Inositol (MI) into D Chiro Inositol. (DCI) Adding more DCI isn’t the answer.
In PCOS patients with hyperinsulinemia, increased epimerase activity leads to excessive conversion of MI to DCI in the ovary, resulting in MI depletion and DCI overproduction (Nestler & Unfer, 2015; Unfer et al., 2014).
This imbalance may impair FSH signaling and oocyte quality (Nestler & Unfer, 2015). Studies have shown that the MI:DCI ratio in follicular fluid drops from 100:1 in healthy women to 0.2:1 in PCOS patients (Unfer et al., 2014).
The altered MI:DCI ratio may contribute to pathological steroidogenesis in PCOS, with DCI promoting androgen synthesis and reducing estradiol production (Unfer et al., 2020).
Restoring the appropriate MI:DCI ratio has shown efficacy in PCOS treatment, and MI supplementation may improve oocyte and sperm quality in assisted reproduction (Facchinetti et al., 2016).
In addition D-Chiro has negative long term effects.
Please read:
Nordio, M.; Bezerra Espinola, M.S.; Bilotta, G.; Capoccia, E.; Montanino Oliva, M. Long-Lasting Therapies with High Doses of D-chiro-inositol: The Downside. J.Clin. Med. 2023, 12, 390. https://doi.org/10.3390/jcm12010390
R. GAMBIOLI, G. FORTE, C. ARAGONA, A. BEVILACQUA, M. BIZZARRI, V. UNFER. The use of D-chiro-Inositol in clinical practice European Review for Medical and Pharmacological Sciences 2021; 25: 438-446
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